癫痫患者脑脊液β_2-微球蛋白的改变

The Changes of Cerebrospinal Fluid β2-microglobulin Patients with Epilepsy

本文应用^(125)Ⅰ放射免疫法对72例癫痫(包括44例原发性癫痫和28例继发性癫痫)和21例坐骨神经痛患者脑脊液中β_2-微球蛋白含量进行了测定。结果显示:继发性癫痫患者脑脊液β_2-微球蛋白(1191.13±332.5μg/L,x±s)显著高于原发性癫痫(695.28±346.66μg/L,x±s)及对照组(776.75±388.59μg/L)(P<0.01),表明β_2-微球蛋白虽是非特异性诊断指标,但对鉴别继发性癫痫和原发性癫痫具有一定价值。

β2-microglobulin (β2-mG) concentrations in the cerebrospinal fluid (CSF) from 72 cases of epilepsy (including 44 cases of idiopathic epilepsy and 28 cases of symptomatic epilepsy) and 21 cases of sciatia were determined with 125I-RIA(Radioimmunoassay).The results showed that the levels of β2-mG in CSF in patients with symptomatic epilepsy (1191.13±332.5) were significantly higher than those in patients with idiopathic epilepsy (695.28±346.66) and in normal controls (776.75±388.59) (P<0.01).Although β2-mG is a non-specific diagnostic parameter,it proves of some value in distinguishing symtomatic epilepsy from idiopathic epilepsy.