复方苦参注射液联合IL-2治疗老年肺癌恶性胸腔积液的临床观察

Clinical observation on compound matrine injection plus interleukin-2 in the treatment of malignant pleural effusion induced by lung cancer in elder

目的:观察复方苦参注射液联合IL-2治疗老年肺癌恶性胸腔积液的疗效和不良反应。方法:60例老年肺癌恶性胸腔积液患者随机分为治疗组和对照组,治疗组:每周1次胸腔内注入复方苦参注射液30 mL+IL-2 200万U+生理盐水20 mL+2%利多卡因针5 mL,连用4周。对照组:每周1次胸腔内注入IL-2 200万U+生理盐水20 mL+2%利多卡因针5 mL,连用4周。4周后观察两组的疗效、生活质量(KPS评分)及不良反应。结果:复方苦参注射液联合IL-2治疗老年肺癌恶性胸腔积液的有效率为86.7%,明显优于单用IL-2组的63.3%,差异有统计学意义(P<0.05);治疗后两组Karnofsky评分中>70分组,治疗组明显高于对照组,其差异有统计学意义(P<0.05);在不良反应中,治疗组除发热以外,胸痛、恶心、呕吐等毒副反应的发生率明显较对照组减少,其差异有统计学意义(P<0.05)。结论:复方苦参注射液联合IL-2治疗老年肺癌恶性胸腔积液疗效肯定,能提高患者生活质量,不良反应少,是治疗老年肺癌恶性胸腔积液的理想选择。

AIM：To evaluate the efficacy and toxicity of pleural perfusion with compound matrine injection plus interleukin-2 in the treatment of elderly patients diagnosed as malignant pleural effusion induced by lung cancer. METHODS：60 elderly patients diagnosed as malignant pleural effusion induced by lung cancer were randomized to either therapy group or control group：the patients＇ pleural cavity in the therapy group were infused with compound matrine injection 30 mL plus interleukin-2 2 milion IU,while the pleural cavity of the control group were infused with interleukin-2 2million IU.The treatment of two group were repeated after a week for a total of four times.After four weeks,the efficacy,quality of life and side effect were recorded.RESULTS：The response rate（RR） in the therapy group were significantly higher than these in the control group（86.7% vs 63.3%,P0.05）;The KPS scores（70）in the therapy group was significantly higher than that in the control group after treatment（P0.05）.The adverse effects of chest pain,nausea and disgorging in the therapy group wese significantly lower than these in the control group（P0.05）,except fever.CONCLUSION：Compound matrine injection plus interleukin-2 shows proved efficacy and slight side-effect for elderly patients diagnosed as malignant pleural effusion induced by lung cancer efficacy in that the quality of life of the elderly has been improved,thus it serves as an effective regimen for elderly malignant plural effusion patients.