放射性肺损伤研究进展

Research progress of radiation-induced lung injury

目的:回顾和总结国内外放射性肺损伤的研究进展。方法:应用Pubmed和CNKI期刊全文数据库检索系统,以"胸部肿瘤、放射性肺损伤"为关键词,检索1998-01-2009-01有关放射性肺损伤的文献。纳入标准:1)放射性肺损伤的分子生学机制;2)放射性肺损伤的临床影响因素及防治。根据纳入标准分析34篇文献。结果:与放射性肺损伤的发生发展密切相关的细胞因子主要包括转化生长因子-β(TGF-β)、血小板源性生长因子(PDGF)和肿瘤坏死因子(TNF-α)等。剂量体积参数V20、V30、MLD和基础肺功能等成为预测放射性肺损伤的因素,阿米福汀、还原型谷胱甘肽及中医中药对放射性肺损伤均有一定防治作用。结论:期待更有效的治疗方法应用于临床,减轻放射性肺损伤。

OBJECTIVE：To review the progress of research on radiation-induced lung injury.METHODS：With ＂radiation-induced lung injury＂ and ＂chest tumor＂ as key words ,the literature was searched in Pubmed and CNKI data-bases between 01-1998 and 01-2009.Choice criteria： 1） molecular biology machanism;2） clinical factors,prevention and treatment of radiation-induced lung injury.A total of 34 literatures were selected.RESULTS：Radiation pneumonitis and pulmonary fibrosis are dose-limiting side effects of radiotherapy for lung cancer.Cytokines such as TGF-β,PDGF and TNF-α are associated with radiation-induced lung injury.Dose-volumetric parameters V20,V30,MLD and foundation lung function are predictors of developing radiation injury.AMF,GSH and traditional Chinese medicine have certain ability to treat radiation injury.CONCLUSION：More effective methods are expected to be explored to reduce radiation injury.