铝碳酸镁联合奥美拉唑预防重型颅脑损伤后急性胃黏膜病变的疗效

Effects of hydrotalcite plus omeprazole on prevention of acute gastric mucosa lesion after severe craniocerebral injury

目的：探讨铝碳酸镁联合奥美拉唑预防重型颅脑损伤后急性胃黏膜病变的疗效。方法：2008年1月至2010年1月本院重症监护病房（ICU）收治的142例重型颅脑损伤患者，随机分为2组，每组71例。A组给予铝碳酸镁联合奥美拉唑预防急性胃黏膜病变，B组仅给予奥美拉唑，观察治疗7d内2组患者急性胃黏膜病变的发生率并进行比较。结果：治疗7d内，A、B2组患者急性胃黏膜病变的发生率分别为5．6％（4／71）、19．7％（14／71），A组患者急性胃黏膜病变的发生率较B组明显降低（P〈0．05）。结论：铝碳酸镁联合奥美拉唑可明显降低患者重型颅脑损伤后急性胃黏膜病变的发生。

Objective：To investigate the effects of hydrotalcite plus omeprazole on prevention of acute gastric mueosa lesion after severe eraniocerebral injury. Methods： 142 cases with severe craniocerebral injury staying in ICU of our hospital between January 2008 and January 2010 were randomly divided into two groups （ n =71 each）. Patients in Group A received hydrotalcite plus omeprazole while patients in Group B received omeprazole alone for prevention of acute gastric mucosa lesion. The incidences of acute gastric mucosa lesion in both groups within the 7 days of treatment were compared. Results ： During the 7-day treatment, the incidence of acute gastric mueosa lesion was 5.6 % （4/71 ） in Group A, compared significantly with 19.7 % （14/71） in Group B （ P 〈 0.05 ）. Conclusion： Hydrotalcite plus omeprazole may significantly reduce the incidence of acute gastric mucosa lesion after severe craniocerehral injury.