PSA对社区老年男性前列腺癌筛查的临床意义和分析

Clinical significance and analysis of serum prostate specific antigen （PSA） for prostate cancer screening in elderly males at the community level

目的：探讨应用血清前列腺特异性抗原（PSA）在社区50岁以上男性人群中行前列腺癌筛查的临床意义。方法：采用化学发光免疫分析技术检测自2008年7月-2009年7月广州市荔湾区逢源和彩虹两个社区3021名50岁以上的男性血清PsA。对于PSA≥14.0ng／mL前列腺癌可疑病例进行前列腺穿刺活检以确诊。结果：筛查中血清PSA≥4．0ng/mL者占7．0％（210／3021），其中前列腺癌发现率6．0％（18／210），且随着年龄的增加和血清PSA浓度的增加，前列腺癌发病增高。结论：用血清PSA在社区老年男性人群中筛查前列腺癌是可行的，可以早期发现前列腺癌，筛查可为这些患者提供有效的治疗机会。

Objective：To investigate the clinical significance of serum prostate specific antigen （PSA） for prostate cancer screening in males aged above 50 at the community level. Methods： Chemiluminescent immunoassay was used to detect PSA among 3021 males aged above 50 from Fengyuan and Caihong Communities, Liwan District, between July 2008 and July 2009. Prostate needle puncture was performed in subjects suspected of prostate cancer （PSA ≥4.0ng/ml ） for a confirmed diagnosis. Results：Among a total of 3021 males, 210 （7. 0% ） were with serum PSA ≥4. 0ng/ml; of these subjects, 18 （6.0%） were diagnosed with prostate cancer. In addition, the incidence of prostate cancer increased along with advanced age and higher level of serum PSA. Conclusion： Measurement of serum PSA appeared feasible for prostate cancer screening in elderly males at the community level, which may allow for early detection and provide chances for effective therapy in the patients.