血管生物反应器流场的数值分析

Numerical analysis on flow field in a vascular bioreactor

目的研究一种新型小口径血管生物反应器在不同工况下的流场分布。方法采用数值方法模拟反应器外筒单独旋转、内筒单独旋转和内外筒同向等速旋转情况下其内部的流场分布,对流速和切应力等参数进行比较分析。结果血管生物反应器工作时,培养液随内外筒的旋转而旋转流动,速度分布均匀;可为培养液内的细胞提供非破坏性的低切应力环境;并且反应器内部的切应力大小与转速呈二次函数关系。结论该反应器能为血管培养提供良好的培养环境,本研究可为其实验研究提供指导意见和理论基础。

Objective To study the flow field of a new vascular bioreactor with small diameter at different operating conditions.Method To investigate the flow field of a new vascular bioreactor with small diameter under three operating conditions by numerical simulation：outer-box rotating,inner-box rotating and both inner-box and outerbox rotating.A comparison of parameters such as flow velocity and shear stress was made.Results The culture medium in the bioreactor rotated with the inner-box and outer-box,and the velocity was uniformly distributed;the bioreactor could therefore provide a low shear stress environment that is nondestructive for the cells in the medium;the shear stress in bioreactor had a quadratic function relation with the rotation rate.Conclusions This bioreactor could provide a good culture environment for vascular tissue regeneration,and this study provided theoretical basis for the experimental research of bioreactors.