速尿对豚鼠耳蜗生物电的影响

EFFECT OF FUROSEMIDE ON THE COCHLEAR BIOELECTRIC POTENTIAL IN GUINEA PIGS

目的观察速尿对豚鼠耳蜗微音器电位（ＣＭ）和听神经动作电位（ＡＰ）的影响。方法给豚鼠１次静脉注射速尿５０ｍｇ／ｋｇ体重，测定注射前、后不同时间的ＣＭ和ＡＰ。结果注射速尿后ＣＭ和ＡＰ的波幅立即降低，２ｍｉｎ达最低水平，３ｍｉｎ开始恢复，４０ｍｉｎ恢复接近正常水平；ＡＰ潜伏期亦在注射速尿后立即延长，２ｍｉｎ达最大值，３ｍｉｎ开始恢复，３０ｍｉｎ恢复接近正常水平。结论速尿对耳蜗ＣＭ和ＡＰ有显著的抑制效应，在本实验剂量１次用药这种抑制是可逆的。

Objective:To observe the effect of furosemide on the cochlear microphonic potential (CM) and auditory nerve potential (AP).Methods:The CM and Ap were examined before and after giving furosemide intravenously (50mg/kg body weight).Results:The wave amplitudes of CM and AP were reduced after injecting drug immediately and reached lowest at two minutes.The amplitudes of CM and AP began to resume at three minutes,and resume its' normal level about at forty minutes after giving drug.Prolongation of AP wave incubation period was observed immediately after giving drug and prolonged maximun value at two minutes.It began to resume at three minutes,and resume its'normal level at about thirty minutes after giving drug.Conclusions:The cochlear bioelectric potential are inhibited remarkably by furosemide.The inhibition effect are reversible after giving drug once.