摘要
目的研究硒（Ｓｅ）铁（Ｆｅ）微量元素异常时心肌细胞损害的机理。方法用细胞内微电极技术分别测定饲养１４周后大鼠心肌细胞电生理的改变。结果与对照组相比，单纯高Ｆｅ组无变化；单纯低Ｓｅ组ＲＰ、ＡＰＡ降低、ＡＰＤ５０延长；低Ｓｅ并高Ｆｅ组ＲＰ、ＡＰＡ也降低，但与低Ｓｅ组相比无显著性差异，ＡＰＤ５０则明显延长。提示低Ｓｅ是心肌细胞损害的基本原因。
Objective:To elucidate the etiology of the impairment of myocardial cells caused by synergic effect of abnormal Se and Fe.Methods:With introcellular microelectrode technique,We observed the electrophysiological properties of the rat fed with abnormal Se and Fe fodder after 14 weeks.Results:Compared with the control,there is no electrophysiological changes in high Fe group;However,in low sethigh Fe group,RP and APA were decreased,APD50 was prolonged;In low sethigh Fe Group,RP and APA were decreased too,APD50 was prolonged significantly.It suggested that low Se led to the impairment of the myocardial cells and high Fe played the synergic effect in this caurse
出处
《泰山医学院学报》
CAS
1999年第2期94-96,共3页
Journal of Taishan Medical College
关键词
硒
铁
心肌电生理
协同性影响
selenium
ferrum
electrophysiology of myocardial cells
