丝裂霉素-甲壳素结合体在肝癌化疗中的临床研究

THE PRIMARY CLINICAL STUDY ON THE CONJUGATED BODY OF MITOMYCIN C AND CHITIN IN TREATMENT OF HEPATIC CANCER

目的：本文介绍了抗癌药物丝裂霉素（ＭＭＣ）与高分子化合物甲壳素的不溶性结合体的制备、灭菌、稳定性及四例肝癌患者应用该合体，行肝动脉灌注栓塞术的初步结果。方法：１）将ＭＭＣ结合体封于安瓿中，用１×１０４ＧＹ剂量的６０Ｃｏ照射，干照射后立即及３年后进行无菌检查，及紫外光谱检查。２）对４例肝癌患者经肝动脉导管入ＭＭＣ结合体或ＭＭＣ，观察肿块缩小率及不良反应。结果：１）结合体经６０Ｃｏ辐照通常达到药典对注射剂的无菌要求。２）结合体中ＭＭＣ对６０Ｃｏ１×１０４ＧＹ剂量辐照是稳定的。３）４例肝癌患者应用该结合体一次经导管给药，其中３人肿瘤缩小持续３～１２个月，对骨髓细胞及肝肾的毒副作用也相对较小。结论：１）结合体经６０Ｃｏ辐照灭菌方法可行。２）经肝动脉导管给药，ＭＭＣ结合体对原发性肝癌有效，并且副作用减小。

OBJECTIVE :Prepartion of the conjugated body (of mitomycin C and chitin)and its primary clinical effect in treatment of hepatic cancer by arterial infusion embolism. METHODS :1) Ampoules were filled with the conjugated body and sealed and sterilized with 60 Co of 1104GY then sterility test were performed after immediate radiation and 3 years later.2) Four patients with hepatic cancer were treated with the conjugated body given by route of arterial duct and its effect and adverse reactions were observed. RESULTS :1) The sterility of 60 Co radiation met the requirements of pharmacopeia and mitomycin C in the conjugated body was stable to radiation dosage of 1104GY.2)The size of the cancer in 3 of the 4 patients was reduced by 34.8% and sustained for 312 months after one single dose of the conjugated body with low toxicity in bone marrow cells and kidney. CONCLUSION :1) 60 Co radiation is an effective method for sterilization of the conjugated body.2)The conjugated body is an effective agent for treatme