摘要
目的:观察芬太尼透皮贴剂(多瑞吉)对晚期癌症伴重度疼痛患者的镇痛效果及其不良反应。方法:采用多中心随机自身对照及开放试验设计,对照药选用缓释吗啡片,二种药物均采用滴定法给药原则,至24h无疼痛或基本不痛为止。多瑞吉q72h一贴,缓释吗啡q12h一次。评价指标为疼痛强度、疼痛缓解率、生活质量等。结果:多瑞吉可使患者的疼痛强度降低到3.0以下,中度疼痛缓解率达到100%,生活质量明显改善。与对照组相比,不良反应略低,但无显著性差异。结论:多瑞吉可有效地控制上述疼痛,不良反应较低,患者接受程度好。
OBJECTIVE :To evaluate the efficacy and safety of transdermal fentanyl in treatment of severe cancer pain. METHODS :32 patients were recruited into a randomized,open, twoperiod,crossover study to compare transdermal fentanyl with a sustainedrelease oral morphine and another 38 patients were recruited into an open study.The fentanyl patches were replaced every 72 h and sustainedrelease morphine was administrated every 12 h. RESULTS]:Pain relief was good throughout the study with side effects,such as dizziness and nausea,similar to that of sustainedrelease morphine.
出处
《中国新药杂志》
CAS
CSCD
1999年第7期487-490,共4页
Chinese Journal of New Drugs
关键词
芬太尼
透皮贴剂
多瑞吉
癌症止痛
Fentanyl
Transdermal system
Durogesic
Analagesic of cancerrelated pain