芬太尼透皮贴剂用于癌症止痛临床效果评价

CLINICAL EVALUATION OF ANALGESIC EFFECT OF TRANSDERMAL FENTANYL ON CANCER PAIN

目的：观察芬太尼透皮贴剂（多瑞吉）对晚期癌症伴重度疼痛患者的镇痛效果及其不良反应。方法：采用多中心随机自身对照及开放试验设计，对照药选用缓释吗啡片，二种药物均采用滴定法给药原则，至２４ｈ无疼痛或基本不痛为止。多瑞吉ｑ７２ｈ一贴，缓释吗啡ｑ１２ｈ一次。评价指标为疼痛强度、疼痛缓解率、生活质量等。结果：多瑞吉可使患者的疼痛强度降低到３．０以下，中度疼痛缓解率达到１００％，生活质量明显改善。与对照组相比，不良反应略低，但无显著性差异。结论：多瑞吉可有效地控制上述疼痛，不良反应较低，患者接受程度好。

OBJECTIVE :To evaluate the efficacy and safety of transdermal fentanyl in treatment of severe cancer pain. METHODS :32 patients were recruited into a randomized,open, twoperiod,crossover study to compare transdermal fentanyl with a sustainedrelease oral morphine and another 38 patients were recruited into an open study.The fentanyl patches were replaced every 72 h and sustainedrelease morphine was administrated every 12 h. RESULTS]:Pain relief was good throughout the study with side effects,such as dizziness and nausea,similar to that of sustainedrelease morphine.