二巯丙磺钠对乙基硫代磺酸乙酯(抗菌剂402)解毒机制研究

Study of antidotal mechanism of sodium dimercaptopropanesulfonate on ethyl thioethylsulfonate

目的：研究二巯丙磺钠对乙基硫代磺酸乙酯（ 抗菌剂４０２ ，ｅｔｈｙｌ ｔｈｉｏｅｔｈｙｌｓｕｌｆｏｎａｔｅ ， 简称 Ｅ Ｔ） 解毒机制。方法： 通过抑菌作用实验，小鼠的急性毒性实验，小鼠耳急性炎症实验，巯基的化学鉴别和薄层层析，研究二巯丙磺钠对 Ｅ Ｔ 的化学性拮抗作用。结果：二巯丙磺钠与 Ｅ Ｔ 混合后， 可以使 Ｅ Ｔ 的抗菌作用、急性毒性和致炎作用明显减弱；２ 药混合后，溶液中二巯丙磺钠的巯基消失和 Ｅ Ｔ 的结构被破坏。结论：二巯丙磺钠与 Ｅ Ｔ 混合后，两者发生了化学反应，呈现化学性拮抗作用。

AIM: To study the antidotal mechanism of sodium dimercaptopropanesulfonate(Na-DMPS) on ethyl thioethylsulfonate(ET). METHODS: Experiments of antibacterial action , acute toxicity on mice,acute inflammation on ears of mice, sulfhydryl groups detection and thin_layer chromatography were made to study the chemical antagonism of Na_DMPS on ET. RESULTS: After mixed ET and Na_DMPS, the antibacterial action of ET and its acute toxicity and inflammatory action were weakened significantly. Sulfhydryl groups of Na_DMPS vanished and the structure of ET was destroyed. CONCLUSIONS: Chemical reaction occurres in the mixed liquid of ET and Na_DMPS. The chemical antagonism of Na_DMPS on ET is manifested.