国产与进口蒙脱石治疗小儿急性腹泻的比较

Domestic vs imported smectite in treatment of acute diarrhea in children

目的：比较国产与进口蒙脱石（ｓｍｅｃｔｉｔｅ） 治疗小儿急性腹泻的疗效。方法：６２ 例急性腹泻病人随机分成国产蒙脱石组３０ 例（ 男性２２ 例，女性８ 例，年龄２１ ｍｏ ±ｓ１６ ｍｏ） 予国产蒙脱石治疗，进口蒙脱石组３２ 例（ 男性２２ 例，女性１０ 例，年龄２０ ｍｏ ±５ｍｏ） 予进口蒙脱石治疗，剂量均为：年龄＜ １ ａ 为３ｇ／ｄ ；１ ～２ ａ 为３ ～６ ｇ／ｄ ；２ ～３ ａ 为６ ～９ ｇ／ｄ ； ＞ ３ ａ为９ ｇ／ｄ ，分３ 次加温水５０ ｍ Ｌ 口服，疗程３ ｄ 。进行疗效观察，并观察不良反应。结果：国产蒙脱石组总有效率为９３ ％ ，与进口蒙脱石组（９４ ％ ） 比较，２ 组差别无显著意义（ Ｐ＞ ０ ．０５） 。不良反应小。结论：国产蒙脱石治疗小儿急性腹泻安全、有效，与进口蒙脱石相仿。

AIM: To compare the efficiency of smectite in the treatment of acute diarrhea in children. METHODS: Sixty_two patients with acute diarrhea were randomly received domestic smectite (n=30) and imported smectite (n=32), <1 a, 3 g/d; 1_2 a, 3_6 g/d; 2_3 a, 6_9 g/d; >3 a, 9 g/d, for 3 d as a course. RESULTS: There were no significant difference of total effective rate between both group (93% vs 94%), and less adverse reaction were found. CONCLUTION: Domestic smectite is an effective and safe agent for treatment of acute diarrhea in children. Its effect is same as imported smectite.