摘要
目的:观察蒙脱石治疗复发性口腔溃疡的疗效。方法:复发性口腔溃疡病人102 例,随机分成3组。蒙脱石组32 例( 男性14 例,女性18 例,年龄32 a ±s 10 a) , 喷蒙脱石0 .1 ~0 .2 g 于溃疡处,每日4 次;氯己定组34 例( 男性16 例,女性18 例,年龄32 a ±9 a) ,用2 % 氯己定液漱口,每日4 次;蒙脱石加氯己定组36 例( 男性16 例,女性20 例,年龄32 a ±11 a) ,先用2 % 氯己定液漱口,然后再喷蒙脱石0 .1 ~0 .2 g , 每日4 次。3 组疗程均为4 d 。结果:蒙脱石组与氯己定组的总有效率分别为81 % 和85 % ,2 组比较差异无显著意义( P> 0 .05) , 而蒙脱 石加氯己定组的总有效率为97 % ,分别与上述2 组比较差异有显著意义( P< 0 .05) 。结论:蒙脱石对治疗复发性口腔溃疡有效,与氯己定合用疗效更佳。
AIM: To observe the efficacy of smectite in treating aphthous stomatitis. METHODS: One hundred and two patients with recurrent ulcer of mouth were randomly divided into 3 groups. Thirty_two patients (M 14, F 18, age 32 a±s 8 a) in smectite group were sprayed 0.1_0.2 g of smectite on the ulcer surface, qid for 4 d; 34 patients (M 16, F 18, age 32 a±9 a) in chlorhexidine group gargled with 2% of chlorhexidine solution, qid for 4 d; 36 patients (M 16, F 20, age 32 a±11 a ) in chlorhexidine plus smectite group gargled first with 2% of chlorhexidine solution, and then were sprayed 0.1_0.2 g of smectite. RESULTS: The total effective rate 81% in smectite group was similar to that of chlorhexidine group 85%(P>0.05), but was lower than that of smectite plus chlorhexidine group 97% (P<0.05). CONCLUSION: Smectite and chlorhexidine in combination gave a better therapy than either drug alone.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1999年第4期228-230,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
蒙脱石
氯已定
口疮性口炎
治疗
smectite
chlorhexidine
aphthous stomatitis