蒙脱石和氯己定治疗复发性口腔溃疡

Smectite and chlorhexidine in treating aphthous stomatitis

目的：观察蒙脱石治疗复发性口腔溃疡的疗效。方法：复发性口腔溃疡病人１０２ 例，随机分成３组。蒙脱石组３２ 例（ 男性１４ 例，女性１８ 例，年龄３２ ａ ±ｓ １０ ａ） ， 喷蒙脱石０ ．１ ～０ ．２ ｇ 于溃疡处，每日４ 次；氯己定组３４ 例（ 男性１６ 例，女性１８ 例，年龄３２ ａ ±９ ａ） ，用２ ％ 氯己定液漱口，每日４ 次；蒙脱石加氯己定组３６ 例（ 男性１６ 例，女性２０ 例，年龄３２ ａ ±１１ ａ） ，先用２ ％ 氯己定液漱口，然后再喷蒙脱石０ ．１ ～０ ．２ ｇ ， 每日４ 次。３ 组疗程均为４ ｄ 。结果：蒙脱石组与氯己定组的总有效率分别为８１ ％ 和８５ ％ ，２ 组比较差异无显著意义（ Ｐ＞ ０ ．０５） ， 而蒙脱 石加氯己定组的总有效率为９７ ％ ，分别与上述２ 组比较差异有显著意义（ Ｐ＜ ０ ．０５） 。结论：蒙脱石对治疗复发性口腔溃疡有效，与氯己定合用疗效更佳。

AIM: To observe the efficacy of smectite in treating aphthous stomatitis. METHODS: One hundred and two patients with recurrent ulcer of mouth were randomly divided into 3 groups. Thirty_two patients (M 14, F 18, age 32 a±s 8 a) in smectite group were sprayed 0.1_0.2 g of smectite on the ulcer surface, qid for 4 d; 34 patients (M 16, F 18, age 32 a±9 a) in chlorhexidine group gargled with 2% of chlorhexidine solution, qid for 4 d; 36 patients (M 16, F 20, age 32 a±11 a ) in chlorhexidine plus smectite group gargled first with 2% of chlorhexidine solution, and then were sprayed 0.1_0.2 g of smectite. RESULTS: The total effective rate 81% in smectite group was similar to that of chlorhexidine group 85%(P>0.05), but was lower than that of smectite plus chlorhexidine group 97% (P<0.05). CONCLUSION: Smectite and chlorhexidine in combination gave a better therapy than either drug alone.