摘要
目的:研究国产蒙脱石对番泻叶引起的小鼠腹泻的止泻作用和对结肠炎症的抑制作用。方法:小鼠50 只,随机均分成5 组,0 .9 % 氯化钠溶液对照组和4 个给药组,给药组分别以国产蒙脱石6 ,9 ,12g/kg ,ig 和进口蒙脱石9 g/kg ,ig , 30 min 后给番泻叶4 g/kg ,ig 。另取小鼠30 只,随机均分成3 组,0 .9 % 氯化钠溶液对照组和2 个给药组,给药组分别给国产蒙脱石和进口蒙脱石9 g/kg ,ig ,1 h 后再以番泻叶10 g/kg ,ig 。结果:国产蒙脱石能明显抑制番泻叶引起的小鼠腹泻,作用呈剂量依赖性;还能减轻由番泻叶引起的结肠炎症。结论:国产蒙脱石对番泻叶引起的小鼠腹泻和结肠炎症有抑制作用,作用强度与进口蒙脱石相似。
AIM: To study the antidiarrheic effect of domestic smectite (Sme) on diarrhea in mice induced by senna. METHODS: Fifty mice were divided into 5 groups at random: (1) the control; (2) Domestic Sme 6, 9, 12 g/kg ig or imported Sme 9 g/kg, ig, 30 min later, senna (4g/kg, ig) was given to each mouse. Another thirty mice were divided into 3 groups at random: (1) the control; (2) drug prevention: Domestic Sme or imported Sme(9g/kg, ig) were administered. An hour later, senna (10 g/kg, ig) was given. RESULTS: As compared with control group Domestic Sme reduced the frequency of diarrhea induced by senna (P<0.05 or P<0.01) in a dose_dependent manner. Domestic Sme also inhibited the colitis induced by senna. CONCLUSION: Sme inhibited the diarrhea and colitis induced by senna in mice. The effects of domestic Sme were similar with imported product.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1999年第4期230-232,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
药理
蒙脱石
番淀叶
止泻药
结肠炎
硅酸铝类
smectite
senna
antidiarrheals
colitis
aluminum silicates
magnessium silicates
mice