怀山药多糖铁治疗缺铁性贫血小鼠的研究

Experimental Study of Dioscorea Rhizoma Polysaccharide-Fe Complex on Mice with Iron Deficiency Anemia

目的:考察山药多糖铁复合物对缺铁性贫血小鼠的治疗效果,为山药多糖铁的开发与应用提供理论依据。方法:采用给予低铁饲料结合定期少量放血的方法建立缺铁性贫血小鼠模型,检测给药前后血红蛋白(Hb)、红细胞计数(RBC)的变化。结果:山药多糖铁PIC(Ⅱ)35 mg.kg-1组各项检测指标与模型组比较,差异有显著性(P<0.05),实验后Hb和RBC基本恢复至正常水平。各受试药与相应剂量的对照品比较,35 mg.kg-1 PIC(Ⅱ)Hb显著高于PS(Ⅱ)(P<0.05)。结论:山药多糖铁复合物具有较好的治疗缺铁性贫血作用,有望开发成为一种新型的补铁剂。

Objective：To investigate the therapeutic efficacy of Dioscorea Rhizoma polysaccharide iron complex（PIC） on mice with iron deficiency anemia（IDA）.Method： Mice model with IDA was prepared by offering low-iron feeds combining with periodic sparing bloodletting.Changes of the indexes such as hemoglobin and red blood cell count were determined.Result： There was significant difference between the indexes of the PIC（Ⅱ） group of 35 mg.kg-1 and those of the model group（P 0.05）,the indexes of Hb and RBC were restored to normal level at the end of the experiment.Compared the indexes of experimental groups with the control groups of corresponding dosage,the PIC（Ⅱ） group was significantly higher than PS（Ⅱ） group（P 0.05）.Conclusion： Dioscorea Rhizoma polysaccharide iron complex not only has superior therapeutic efficacy on IDA,but also has the effect on enriching and harmonizing blood,which the Dioscorea Rhizoma polysaccharide does.