白花银背藤抗炎作用研究

Study on Anti-inflammatory Effect of Argyreia seguinii

目的:考察白花银背藤的抗炎作用。方法:将实验动物随机分为5组,每组10只,分别为模型对照组,阿司匹林组,白花银背藤高、中、低剂量组(按生药量计为19.0,13.6,8.2 g.kg-1),连续ig给药7 d,采用小鼠耳廊肿胀法、大鼠足跖肿胀法、大鼠棉球肉芽肿法考察抗炎作用。结果:白花银背藤能抑制巴豆油致小鼠耳肿胀(P<0.05～P<0.01),能抑制角叉菜胶致大鼠足跖肿胀(P<0.05),并能减轻大鼠棉球肉芽肿质量(P<0.05)。结论:白花银背藤具有一定的抗炎作用。

Objective：To study the anti-inflammation effect of Argyreia seguinii.Method： The animals were given orally with A.seguinii daily（at doses of 19.0,13.6,8.2 g.kg-1 accordingly） for 7 days.Model of ear swelling in mice,model of paw edema in rats and model of cotton granuloma in rats were adopted to observe the anti-inflammatory effects.Result： A.seguinii could inhibit the ear swelling induced by the croton oil（P 0.05 or P 0.01）,inhibit the swelling of the paw in rats with the carrageenan（P 0.05）,and reduce the weight of cotton granuloma in rats（P 0.05）.Conclusion： The results indicates that A.seguinii has anti-inflammatory effect.