参附汤加味与复方丹参注射液联用治疗新生儿硬肿症32例

Treatment with Shenfu Decoction(参附汤) combined with composite salvia miltiorrhiza injection for 32 cases with scleredema neonatorum

目的：观察参附汤与复方丹参注射液联用治疗新生儿硬肿症的临床疗效。方法：６２例新生儿硬肿症患儿随机分为２组。治疗组（３２例）在常规治疗基础上给予鼻饲或口服中药参附汤加味和静滴复方丹参注射液。对照组３０例只采用常规西药治疗。观察２组疗效。结果：治疗组与对照组总有效率分别为９３．７５％和６０．００％（Ｐ＜０．０１）；硬肿消退时间分别为（３．３５±０．３９）日与（４．５３±０．４５）日（Ｐ＜０．０１）；硬肿缓解时间分别为（３．７０±０．２６）日与（５．４８±０．４１）日（Ｐ＜０．０１）。结论：参附汤加味和复方丹参注射液联用具有活血化瘀、扩张血管、恢复体温和皮温、抗炎、抗休克、举阳回逆作用；

Objective:To investigate the clinically curative effects of integrated traditional Chinese medicine(TCM) and western medicine (WM) on scleredema neonatorum (SN).Methods:62 cases with SN were randomly divided into two group.The treatment group ( n =32) based on conventional therapy were treated with Shenfu Decoction(参附汤) plus some herbs given by nasogastrictube feed or orally and composite salvia miltiorrhiza injection infused intravenously,otherwise the control group ( n =30) treated with conventional therapy alone.The curative effects were observed for two groups.Results:In treatment group the total effective rate (93 75%),the time for scleredema to subside (3 35±0 39)days ,and the time for relieving (3 70± 0 26)days were significantly better than those 60 00%,(4 53±0 45)days and (5 48 ±0 41)days respectively in control group (all P <0 01).Conclusions:Shenfu Decoction plus some herbs combined with composite salvia miltiorrhiza injection possess the actions on activating the blood circulation to remove blood stasis (活血化瘀),recovering body temperature and skin temperature,antiimflammatory reaction,antishock,and lifting Yang and recuperating aduersity (举阳回逆) and have sufficiently curative effects on treating SN.