榄香烯乳加联合化疗治疗难治性急性非淋巴细胞白血病

Emulsion Elemeni plus Combination Chemotherapy in Treatment of Refractory Acute Nonlymphocytic Leukemia

目的：评价榄香烯乳加联合化疗治疗难治性急性非淋巴细胞白血病。方法：将３０ 例白血病患者随机分为治疗组：用榄香烯乳３００ｍｇ 入５ ％ Ｇ．Ｓ５００ｍｌ 中静脉滴注，持续用药１４ 天，同时用联合化疗：Ａｒａ－ Ｃ０．５ｇ／ｍ２．ｄ ，第１～７ 天；ＶＰ－ １６ １００ｍｇ／ｍ２．ｄ ，第１ ～３ 天；对照组单用联合化疗，方案用量用法同治疗组。结果：治疗组总有效率７７．８ ％ ，对照组总有效率５０ ％ ，差异有显著性（ Ｐ＜ ０．０５）。结论：榄香烯乳对难治性急性非淋巴细胞白血病（ＡＮＬＬ）有肯定疗效，比单用联合化疗效果好，且不良反应少，无血象和骨髓抑制。

Objective: To evaluate the effect of Emulsion Elemeni (Lx) in combination with chemotherapy for refractory acute nonlymphocytic leukemia (ANLL). Methods: Thirty-three patients were randomized into two groups. Eighteen cases were treated with Lx 300mg/day intravenous drip for 14 days, and simultaneously with combination chemotherapy (Arac 0 5g/m 2 /d for 1～7 days; VP-16 100mg/m 2 /d for 1～3 days). The other 12 cases were treated with chemotherapy alone. The dosage and schedule of chemotherapy were the same for the two groups. Results: The study group (18 cases) achieved CR in 10, PR 4, NR 4. Those of the control group (12 cases) CR in 4, PR 2, NR 6 were seen. The response rates of the Lx plus chemotherapy group and chemotherapy alone group were 77 8%(14/18), 50%(6/12 ) respectively ( P<0 05 ). Conclusion: The response to Lx plus chemotherapy in the treatment of refractory ANLL was superior to that of chemotherapy alone. Lx entails no bone marrow depression and its side-effects were slight.