60例肝内胆汁淤积症妊娠母婴结局临床分析

Clinical analysis of maternal and neonatal outcomes about sixty cases of intrahepatic cholestasis of pregnancy

目的:探讨妊娠期肝内胆汁淤积症妊娠结局对母婴的影响。方法:60例肝内胆汁淤积症(ICP)患者为ICP组,取同期60例正常孕妇为对照组,对妊娠结局进行回顾性分析。结果:妊娠期肝内胆汁淤积综合征组并发症,如肝功能受损、血小板减少、早产等与对照组相比明显增加,胎儿窘迫发生例数、剖宫产率、早产儿及新生儿窒息等发生均高于对照组(P<0.05)。结论:妊娠期肝内胆汁淤积症对母婴危害大,早产、胎儿窘迫及围生儿并发症,死亡率明显高于正常孕妇组,加强对ICP组的产前监护及管理,尽量改善母婴结局。

Objective：To investigate the intrahepatic cholestasis of pregnancy on maternal outcome of pregnancy.Methods：60 patients with intrahepatic cholestasis（ICP） ICP group of patients,60 normal pregnant women to take over the same period as the control group,on pregnancy outcome were analyzed retrospectively.Results：The intrahepatic cholestasis syndrome group complications such as impaired liver function,thrombocytopenia,premature delivery compared with the control group significantly increased the number of cases of fetal distress,cesarean section rate and neonatal asphyxia in preterm children such as occurred were higher（P0.05）.Conclusion：Intrahepatic cholestasis of pregnancy on maternal and child against a large,premature delivery,fetal distress and perinatal complications in children,mortality is significantly higher than normal pregnant women group,strengthening the monitoring of ICP and management of the prenatal group,try to improve maternal and child outcome.