液基细胞检测技术在宫颈病变筛查中的应用

The screening role of thinprep cytological test in cervical disease

目的:探讨宫颈液基细胞学技术(thinprep cytologic test,TCT)在宫颈病变筛查中的临床应用价值。方法:选择本院2008年10月～2010年6月进行宫颈液基细胞学检查的患者2000例,按照Bethesda系统(TBS)分类法进行细胞学诊断,对其中的76例行阴道镜下活检,与病理组织学的诊断结果进行比较。结果:2000例患者在宫颈液基细胞学技术检查中的涂片满意率为96.95%(1939/2000),发现异常涂片102例,其中76例患者进行阴道镜下活检,活检结果鳞癌4例,TCT与阴道镜下的活检病理结果的总体符合率为64.47%。结论:宫颈液基细胞学技术(TCT)在宫颈癌筛查中的准确度较高,检查过程中涂片的满意率及宫颈异常细胞检出率也大大提高,TCT配合阴道镜下活检是筛查和诊断子宫颈癌病变的最为有效的手段。

Objective：Discuss the clinical value of thinprep cytological test in diagnosis of early cervical disease.Methods：2 000 patients with thinprep cytology were slectted in our hospital from October 2008 to June 2010,in accordance with the Bethesda System（TBS） for cytology classification,76 of them with routine colposcopic biopsy on histological diagnosis were compared.Results：2 000 cases were thinprep cytology in cervical smear examination in 96.95%（1939/2000） satis faction rate,102 cases of abnormal smears,76 cases were carried out abnormal vaginal biopsy,TCT and colposcopy the biopsy results of the overall complicance rate was 64.47%.Conclusion：Thinprep cervical cytology（TCT） in cervical cancer screening,higher accuracy,the inspection process and the satisfaction rate of cervical amear abnormal cells greatly increase the detection rate,TCT coordinates with colposcopic biopsy is the most effective mean of screening and diagnosing of cervical lesions.