子宫肌瘤与细胞凋亡关系初探

Primary Study on the Relationship between Apoptosis and Human Uterine Leiomyoma

目的探讨子宫平滑肌瘤的发生与细胞凋亡的关系。方法采用免疫组化技术监测子宫肌瘤患者的肌瘤核组织（实验组）及其周围正常肌组织（对照组）中，ｐ５３基因蛋白产物、Ｆａｓ配体（Ｆａｓ－Ｌ）基因蛋白产物及Ｂｃｌ－２基因蛋白产物的表达。结果实验组各项阳性表达：ｐ５３蛋白为３６６７％，Ｆａｓ－Ｌ蛋白为５６６７％，Ｂｃｌ－２蛋白为７７４２％；对照组各项阳性表达：ｐ５３蛋白为２０００％，Ｆａｓ－Ｌ蛋白为９０００％，Ｂｃｌ－２蛋白为４４８３％。实验组Ｆａｓ－Ｌ蛋白的表达明显低于对照组（Ｐ＜００１），而Ｂｃｌ－２蛋白的表达则明显高于对照组（Ｐ＜００１）。结论子宫肌瘤的发生与细胞凋亡异常有密切关系。

Objective\ To investigate the relationship between apoptosis and human uterine leiomyoma.Methods\ The expression of p53,Fas-Ligand and Bcl-2 protein were examined immunohistochemically in leiomyoma(experimental group)and adjacent normal myometrium(control group).Results\ The positive rate of Fas-L in experimental group was significantly lower than that in control group.The postitive rate of Bcl-2 in experimental group was significantly higher than that in control group.No significant difference of the positive rate of p53 between the two groups was observed.Conclusion\ Abnormal apoptosis may play a role in the etiology of human uterine leiomyoma.