铂类与异环磷酰胺联合化疗治疗卵巢复发癌48例临床分析

Combined Chemotherapy with Platinum and Ifosfamide for the Treatment of Recurrent Ovarian Cancer:Clinical Analysis of 48 Cases

目的探索卵巢癌二线化疗方案。方法选择曾接受过肿瘤细胞减灭术及多疗程联合化疗、体检或影像学检查有可测得的肿瘤存在、一个月内无化疗史、未接受过放疗、血象及肝肾功正常、病理证实的卵巢上皮性复发癌患者作为治疗对象。用顺铂或卡铂与异环磷酰胺联合化疗，美施钠解毒。结果４８例病人中无完全缓解者；部分缓解１４例（２９２％）；稳定２２例（４５８％）；无效１２例（２５０％）。不同程度毒副反应病人可以耐受。结论顺铂或卡铂与异环磷酰胺联合化疗可作为卵巢上皮性复发癌补救治疗中的主要手段之一，且副反应病人可以耐受。

\ Objective\ To explore the secondary chemotherapy regimen of ovarian cancer.Methods\ We chose 48 patients who had undergone cytoreductive surgery and many courses of combined chemotherapy,but had no history of radiotherapy and did not receive the chemotherapy within the month.Measurable tumor could be found through physical or radiological examination and was pathologically proved to be epithelial ovarian cancer.All these patients underwent cisplatin/carboplatin and ifosfamide combination chemotherapy.Results\ Among 48 patients,no one had complete remission,14 had partial remission(29.2%),22 steadiness(45.8%),12 had no responses to chemotherapy (25.0%).Side effects could be endured.Conclusion\ Cisplatin/Carboplatin and ifosfamide combination chemotherapy can be one of the main remedial methods for the treatment of recurrent epithelial ovarian cancer.