社区糖尿病危险因素的聚集与HbA_(1c)变化的关联性

The relationship between accumulation of risk factor components and levels of glycated haemoglobin in diabetic patients in community

目的了解社区2型糖尿病(T2DM)人群发病危险因素的聚集与糖化血红蛋白(HbA1c)变化的关联性。方法在城市社区就诊患者中选取159例T2DM患者,进行糖尿病人群危险因素调查、体格指标测量和生化指标检测。结果 (1)在159例T2DM患者中,诊断具有糖尿病危险因素者103人(占64.8%),其HbA1c水平明显高于不伴有糖尿病危险因素者(P<0.01);(2)Logistic回归分析结果显示,有2个危险因素组、3个危险因素组、4个危险因素组和5个危险因素组的HbA1c的OR值平均分别为1.942(1.063～3.514)、3.041(2.182～7.481)、3.900(2.091～9.562)和5.910(3.991～10.562)。结论糖尿病危险因素不仅影响HbA1c水平的变化,而且随着危险因素组分的聚集增高,HbA1c呈阶梯式升高的趋势。

Objective To investigate the relationship between different accumulations of risk factor components and levels of glycated haemoglobin（HbAlc） in type2 diabetic patients. Methods One hundred and fifty-nine diabetic patients from community received epidemlology inquiry, anthropomctric profile and blood biochemical tests. Results （ 1 ） In this population, diabetic patients with risk factor were 103 （64. 8% ）, and the level of glycatcd haemoglobin in those with risk factor was higher than in those without risk factor （P 〈 0.01 ） ; （2）Binary logistic regression analysis revealed that compared with the group without any risk factor component or with only one component, the OR values of the group with 2 risk factor components, with 3 risk factor components, with 4 risk factor components and with all 5 risk factor components on HbAlc were 1. 942 （ 1. 063 - 3. 514）, 3.041 （2. 182 - 7. 481 ） ,3. 900 （2. 091- 9. 562） and 5. 910（3.991 - 10. 562） respectively. Conclusion The study suggested that the accumulations of risk factor components increase the levels of glycated haemoglobin in diabetic patients.