尼卡地平对大鼠肾小球系膜细胞凋亡的诱导

Nicardipine induce apoptosis of mesangial cell in rats in vivo

目的探讨尼卡地平体内对大鼠系膜细胞凋亡的诱导作用。方法分别用脱氧核糖核酸（ＤＮＡ）片断电泳、油镜观察细胞凋亡，浸条法测定蛋白尿和血尿。结果尼卡地平体内能诱导大鼠系膜细胞凋亡，同时伴轻度蛋白尿。结论尼卡地平在体内有诱导大鼠系膜细胞凋亡的作用。这可能是治疗系膜增生性肾小球肾炎的有效药物。

Objective\ To study the effect of nicardipine on rat mesangial cell apoptosis in vivo.Method\ Apoptosis was assessed by DNA gel electrophoresis,oil-immersion microscopy.Proteinuria and hematuria were assessed by dipstick.Result\ Nicardipine can induce rat mesangial cell apoptosis in vivo.Conclusion\ Nicardipine can induce rat mesangial cell apoptosis in vivo,which may be a useful medicine in treating mesangial proliferative glomerulonephritis.