大肠癌及癌旁组织中雌激素、孕激素受体的表达及意义

Significance and expression of estrogen and progesterone receptors in colorectal cancers and their surrounding mucosa

目的探讨大肠癌与雌激素受体、孕激素受体的关系。方法用免疫组化ＡＢＣ法对４３例大肠癌及癌旁组织进行雌激素受体（ＥＲ）、孕激素受体（ＰＲ）检测。结果大肠癌ＥＲ、ＰＲ阳性率分别为８３７２％和８８３７％。癌旁粘膜内也检出ＥＲ、ＦＲ其检出率与癌组织部位相比差异有显著性（Ｐ＜００１）。与年龄、性别、肿瘤部位、分期及有无转移无关，与肿瘤分化程度亦无关（Ｐ＞００５）。结论大肠癌为性激素依赖性肿瘤；癌旁粘膜内检出ＥＲ、ＰＲ的肿瘤预后可能较好；ＡＢＣ法应用在大肠癌中ＥＲ、ＰＲ有较高的检出率。

Objective To investigate the relations among colorectal cancers, estrogen and progesterone.Methods Tissues from 43 primary human colorectal cancers and their surrounding mucosa were examined for estrogen (ER) and progesterone receptors (PR) by using the avidin biotin peroxidase complex(ABC) immunohistochemical method. Results The positive rate of ER and PR in colorectal cancers was 83 72% and 88 37% respectively. There were significant positive relations between the positive rate of ER and PR for cancer tiusses and for surrounding mucosa ( P <0 01). ER and PR were expressed in surrounding mucosa. ER and PR were detected in surrounding mucosa of which their histologic grade were better. They were not related to sex, age of the patients, tumor localization, histologic grade, or stages of Dukes classification( P >0 05). Conclusion The findings suggest that the cancers contain endocrinic characteristics, the prognostic of the patients with ER and PR expression in surrounding mucosa may be better, and more positive ER and PR in colorectal cancers will be found by using ABC.