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阿戈美拉汀治疗失眠症的研究进展 被引量:11

Development of agomelatine in the treatment of insomnia
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摘要 褪黑素能催眠药是近年催眠药物的研究热点。作为褪黑素受体激动剂和5-HT2c受体拮抗剂的阿戈美拉汀,其作用机制独特,受到广泛关注。本品不仅具有抗抑郁作用,还表现出促睡眠效应。本文综述阿戈美拉汀的作用机制,以及其对睡眠的影响和药物安全性、耐药性的研究进展。 Melatonin, a hypnotic drug has been a hot research project in recent years. As a melatonin receptor agonist and 5-HT2c receptor antagonist, agomelatine causes wide attention due to its unique mechanism on antidepressant and sleep-promoting effect. This review describes the development of mechanism, impact on sleep, safety and drug resistance of agomelatine.
作者 陈发展 陆峥
出处 《世界临床药物》 CAS 2011年第4期214-218,共5页 World Clinical Drug
关键词 阿戈美拉汀 褪黑素 催眠作用 失眠症 agomelatine melatonin sleep-promoting effect insomnia
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