摘要
褪黑素能催眠药是近年催眠药物的研究热点。作为褪黑素受体激动剂和5-HT2c受体拮抗剂的阿戈美拉汀,其作用机制独特,受到广泛关注。本品不仅具有抗抑郁作用,还表现出促睡眠效应。本文综述阿戈美拉汀的作用机制,以及其对睡眠的影响和药物安全性、耐药性的研究进展。
Melatonin, a hypnotic drug has been a hot research project in recent years. As a melatonin receptor agonist and 5-HT2c receptor antagonist, agomelatine causes wide attention due to its unique mechanism on antidepressant and sleep-promoting effect. This review describes the development of mechanism, impact on sleep, safety and drug resistance of agomelatine.
出处
《世界临床药物》
CAS
2011年第4期214-218,共5页
World Clinical Drug
关键词
阿戈美拉汀
褪黑素
催眠作用
失眠症
agomelatine
melatonin
sleep-promoting effect
insomnia