沙利度胺联合MP方案治疗老年多发性骨髓瘤临床观察

Clinical study of melphalan and prednisone plus thalidomide in elderly patients with multiple myeloma

目的观察沙利度胺联合MP方案(马法兰、强的松)与单用MP方案比较治疗老年多发性骨髓瘤(MM)的临床疗效及安全性。方法治疗组(24例)口服沙利度胺,同时联合MP方案化疗,每月1个疗程。对照组(22例)单用MP方案化疗,马法兰、泼尼松的剂量和用法同治疗组。在4个疗程后,判断2组疗效及不良反应。结果治疗组总有效率79.16%(19/24),对照组总有效率50%(11/22),2组间差异有统计学意义(P<0.05)。治疗组的皮疹、便秘、嗜睡和水肿较对照组多,其他不良反应2组差异无统计学意义。结论沙利度胺联合MP方案治疗老年MM较单用MP方案疗效更明显,患者耐受性较好,尤其适用于老年患者。

Objective To investigate the effect and safety of thalidomide combinated MP（melphalan,prednisone） protocol on multiple myeloma（MM）.Methods Twenty-four patients with MM in treated group were given thalidomide,the chemical therapy of MP protocol were given at the same time.The course of treatment lasted for one month.Twenty-two patients in control group were given the chemical therapy of MP protocol only.The doses of melphalan and prednisone were as same with treatment group.The effect and safety of treatment had been evalutated after 4 course of treatments.Results The total effective rate was 79.16%（19/24） in the treated group.The total effective rate was 50%（11/ 22） in the control group.Compared with the control group,therapeutic effect had significantly improved in treated group（P0.05）.Adverse drug reaction（ADR） such as rash,constipation,sleepiness and edema,were more common in treatment group,whereas the frequency of other ADR was not significantly diferent in two groups.Conclusion Effect of thalidomide combinated MP protocol on MM was significantly improved than that MP protocol.