度洛西汀与帕罗西汀治疗不同症状抑郁症的比较研究

Comparative study of duloxetine and paroxitine in the treatment of depression with different symptoms

目的比较度洛西汀与帕罗西汀治疗不同症状抑郁症的疗效。方法将126例符合ICD-10抑郁症诊断标准的患者,按不同主诉(精神症状或躯体症状)分为2组,每组再随机分为2个亚组,分别采用度洛西汀(每天60 mg)和帕罗西汀(每天20 mg)治疗6周,用汉密尔顿抑郁量表(HAMD)评定疗效,用副反应量表(TESS)评定药物不良反应。结果在以精神症状为主的患者中,度洛西汀组与帕罗西汀组的有效率分别为84%和75%,两者比较差异无显著性(P>0.05);在以躯体症状为主的患者中,度洛西汀组与帕罗西汀组的有效率分别为80%和55%,两者比较差异有显著性(P<0.05)。结论与帕罗西汀相比,度洛西汀治疗伴有躯体症状的抑郁症患者疗效更好。

Objective To compare efficacy of duloxetine and paroxitine in the treatment of depression with different symptoms.Methods A total of 126 patients who met the criteria of ICD-10 for depression were assigned to two groups based on different complaints（mental or somatic complaints）.Every group was randomly divided into two subgroups treated with duloxetine 60 mg per day or paroxitine 20 mg per day for 6 weeks.The efficacy was assessed by Hamilton depression scale（HAMD）,and the safety was assessed by treatment emergent symptom scale（TESS）.Results The efficacy rates of the dulixetine subgroup and the paroxitine subgroup were 84% and 75% in the patients with mental complaints,there was no significant difference between two subgroups（P0.05）.In the patients with somatic complaints,the efficacy rates of the duloxetine subgroup and the paroxitine subgroup were 80% and 55% respectively,there was significant difference between two subgroups（P0.05）.Conclusion Duloxetine could show better efficacy than paroxitine in the patients with somatic symptoms.