胚胎脊髓移植联合应用神经生长因子、尼莫地平对成鼠损伤脊髓功能的影响

The effects of fetal spinal cord transplantation, nerve growth factor and nimodipine on functional recovery of injured spinal cord in rats

目的：研究胚胎脊髓移植联合应用神经生长因子（NGF）及尼莫地平（ND）对脊髓损伤的修复作用。方法：72只大鼠半切洞脊髓损伤后，随机分为单纯胚胎脊髓移植组，移植＋NGF组，移植＋NGF＋ND组，并观察了脊髓血流量（SCBF），运动诱发电位（MEP）及行为学变化。结果：NGF与ND可明显增加损伤移植部位的血流量，缩短MEP潜伏期，且显著提高后肢运动功能的Tarlov评分。结论；胚胎脊髓移植与NGF、ND联用，可促进大鼠损损伤脊髓功能恢复。

Objective: To observe the therapeutic effects of fetal spinal cord transplantation (FSCT),nerve growth factor (NGF) and nimodipine (ND) on the functional recovery of injured spinal cord. Methods:72 rats were inflicted with hemisectional cavitational injury of the spinal cord and the rats were divided into 2groups; transplantation＋NGF (TN) and transplantation＋NFG＋ND treated (TNN) groups. Spinal cordblood flow (SCBF), motor evoked potential (MEP) and the functions of the hind limbs were observed.Results: NGF and ND could increase SCBF, shorten the latency of MEP and improve the Tarlov score of thefunctions of the hind limbs. Conclusion: FSCT in association with NGP and ND can promote the recovery ofthe motor functions of the rats with hemisectional cavitational injury of the spinal cord.