粪肠球菌的抗生素后效应

The postantibiotic effects of E.faecalis

目的：研究１８ 种抗菌药物对条件致病菌粪肠球菌的抗生素后效应（ＰＡＥ） 。方法：粪肠球菌分离鉴定采用ＶＩＴＥＫ 全自动微生物分析仪；ＭＩＣ测定应用微量平板稀释法；ＰＡＥ采取光密度法。结果：大环内酯类与氟喹诺酮类对粪肠球菌的抗菌作用较强，ＰＡＥ也很长；受试菌对碳青霉烯类和青霉素类在浓度较高时才显示较长的ＰＡＥ；氨基糖苷类的ＰＡＥ 较长，但因粪肠球菌对其耐药，在达到ＭＩＣ时已大大超过中毒剂量；头孢菌素类ＰＡＥ很短。结论：因大环内酯类、氟喹诺酮类、碳青霉烯类或青霉素类对粪肠球菌ＰＡＥ较明显，在设计用药方案时应重视ＰＡＥ的影响，适当延长给药间隔。

OBJECTIVE:The postantibiotic effects(PAEs) of eighteen antimicrobial agents against conditional pathogens E.faecalis were studied.METHODS: E.faecalis were identified by VITEK system.Minimal inhibitory concentrations(MIC) were determined by use of microdiluted method;PAEs were measured using spectrophotometric method.RESULTS:Stronger antibacterial activity and longer PAE of macrolides and fluroquinolones against E.faecalis were seen.The activity of imipenem and penicillins against E.faecalis was high,the PAEs were obvious in high concentrations of the drugs.PAEs of aminoglycosides were long,but their MICs were higher than the toxic concentration.PAE of cephalosporins were short.CONCLUSIONS:In treatment of infections caused by E.faecalis ,macrolides、fluroquinolones、imipenem and penicillins might be effective and the dosing intervals of the drugs can be prolonged.