螺旋藻多糖对小鼠脾细胞中环腺苷酸浓度的影响

Effect Spirulina platensis polysaccharides on cellular cAMP level in murine splenocyte

目的：对螺旋藻免疫调节作用的机理进行研究。方法：采用竞争性蛋白结合分析法，研究螺旋藻多糖（ Ｓｐｉｒｕｌｉｎａ ｐｌａｔｅｎｓｉｓ ｐｏｌｙｓａｃｃｈａｒｉｄｅｓ，ＳＰＰ） 对小鼠脾细胞中第二信使环腺苷酸（ｃＡＭＰ） 浓度的影响。结果：ＳＰＰ可剂量依赖性引起小鼠脾细胞中ｃＡＭＰ浓度的升高。结论：ＳＰＰ免疫调节作用的重要机制之一是对脾细胞中第二信使ｃＡＭＰ浓度的影响。关键词 螺旋藻多糖，环磷酸腺苷。

OBJECTIVE:To study the immunoregulatory action of Spirulina platensis polysaccharides (SPP).METHODS:The impact of SPP on splenocyte cAMP level as the second messenger in mice was in investigated.RESULTS:SPP could increase the cellular cAMP level in splenocyte dose dependently.CONCLUSIONS:The results showed that one of the most important immunoregulatory actions be to affect the cAMP level as the second messenger in spleuocytes.