IgA肾病临床与病理相关性研究

Correlation study of IgA nephropathy and pathology

目的研究IgA肾病(IgAN)临床特征和病理分级的关系,以期指导临床治疗并判断预后。方法回顾性总结经皮肾穿刺确诊为IgAN的65例患者,根据Lee分级,系统分析病理分级与临床指标之间的关系。结果病理学分型中65例患者I、Ⅱ、Ⅲ、Ⅳ、V型各占6.2%、12.3%、38.5%、40.0%、3.1%;病理类型轻者多表现为无症状血尿和(或)蛋白尿,疗效较好,而病理类型重者临床表现多为肾病综合症、肾衰竭伴高血压,疗效差,预后差。结论肾病的临床病理表现多样化,早期及时行肾活检并作病理分型对IgA肾病指导治疗、判断预后有重要的临床意义。

Objective To study IgA nephropathy（IgAN） the clinical features and the relationship between pathological grade,clinical treatment and prognosis.Methods A retrospective summary of percutaneous in 65 patients diagnosed as IgAN patients,according to Lee classification,system analysis and clinical indicators of tumor grade between.Results The pathological types in 65 patients were I,Ⅱ,Ⅲ,Ⅳ,V-type each 6.2%,12.3%,38.5%,40%,3.1%;Most pathology who showed mild asymptomatic hematuria and（or） proteinuria,good effect,and the pathological type of clinical manifestations of severe nephrotic syndrome,renal failure with hypertension,poor efficacy and poor prognosis.Conclusions The clinical pathological kidney diversification,early in time for renal biopsy and pathological classification of IgA nephropathy in guiding treatment and prognosis has important clinical significance.