马来酸依那普利叶酸片治疗老年高血压病的疗效及安全性研究

Efficacy and safety of Enalapril-Folate acid tablets in treatment of elderly hypertensive patients

目的探讨马来酸依那普利叶酸片治疗老年高血压病的疗效及安全性。方法选择75例老年原发性高血压患者随机分配到3个治疗组中,分别接受依那普利10.0 mg、马来酸依那普利叶酸片10.0mg/0.4mg和马来酸依那普利叶酸片10.0mg/0.8mg,每日1次,连续治疗8周。结果两种配比马来酸依那普利叶酸片组降压效果、降低同型半胱氨酸疗效均优于依那普利组(P<0.01)。用药前后血常规、尿常规、电解质、血脂、血糖、肝肾功能均无明显改变(P>0.05)。结论马来酸依那普利叶酸片用于老年高血压患者降压、降低同型半胱氨酸安全、有效。

Objective To investigate the efficacy and safety of Enalapril-Folate acid tablets in the treatment of elderly hypertensive patients.Methods Patients with elderly hypertension were randomly divided into the following three groups： Enalapril 10.0mg/d;Enalapril 10.0mg＋Folic acid 0.4mg/d;Enalapril 10.0mg＋Folic acid 0.8mg/d.The patients were treated for a total period of 8 weeks.Results Both the groups of Enalapril 10.0mg＋Folic acid 0.4mg and Enalapril 10.0mg＋Folic acid 0.8mg had significantly higher effectiveness in lowering both blood pressure and plasma homocysteine level（P0.01）.Adverse reactions were rarely found in both groups（P0.05）.Conclusions Enalapril-Folic acid tablets can be used to reduce both blood pressure and plasma homocysteine level in elderly hypertensive patients.