调节性T细胞与肿瘤研究进展

Advancement in the Research on Regulatory T Cells and Tumor

CD4+CD25+调节性T细胞(regulatory T cells,Treg)是指一类具有免疫调节功能的T淋巴细胞,在维持机体免疫自稳、调控免疫应答方面起重要作用。近年研究表明,Treg细胞也可能通过相同的机制消弱机体的抗肿瘤效应。FOXP3是近年发现的影响Treg生物功能发挥的关键转录因子,是Treg表面特异性标志,是Treg发育和功能发挥的关键基因。综述Treg生物学特性及与肿瘤关系的研究进展。

CD4＋CD25＋regulatory T cells（Treg） is a subset with acknowledged specific function of inhibiting immune responses.CD4＋CD25＋regulatory T cells have been associated with prevention of antitumor immunity and the evasion of efficient recognition of tumor antigens.These T cells play critical roles in immunologic self-tolerance,anti-tumor immune responses,transplantation and so on.Treg cells could inhibit antitumor immunity.FOXP3 serves as an important regulator for the development and function of Treg cells.FOXP3 has emerged as a critical regulator of the development and function of CD4＋CD25＋ Treg cells.The regulatory effect of Treg cells is key in tumor immunotherapy.