生物可降解电活性苯胺聚合物

Electroactive and Biodegradable Aniline Copolymer

导电聚合物通过其独特的电活性或导电性,可智能地传递或控制细胞电化学信号,从而定向诱导组织器官的再生修复,已成为神经和组织工程领域研究的热点。本文主要介绍了我们实验室生物可降解电活性苯胺聚合物的相关工作,介绍了以苯胺齐聚物与可降解高分子接枝或嵌段制备具有电活性、可生物降解的新型导电聚合物及其在细胞培养和组织工程方面的研究。介绍了静电纺丝制备电活性纳米纤维的概况。苯胺齐聚物与可降解聚合物的接枝和嵌段可同时赋予其电活性、生物相容性和生物可降解性。可生物降解的电活性聚合物是未来生物组织工程领域的发展趋势之一,具有广阔的应用前景。

Electroactive and electrically conductive polymers, which can ideally conduct bioelectrical signals in vivo, have shown potential applications in the culture of excitable cells and as electroactive scaffolds for neuronal or cardiac tissue engineering. In this paper, the new research progress of electroactive, biodegradable aniline oligomer grafted copolymers,block copolymers and cell culture were introduced. Recent progresses of electrospinning fibre are reviewed. The materials which are electroactive, remarkably biocompatible and biodegradable,were designed and synthesized by covalently grafting or block-copolymerizing aniline oligomers onto or with biodegradable polymers. The properties of these copolymers are promising for biomedical applications both in vitro and in vivo. Some potentially rewarding research directions are suggested.