药物递送中的高分子原理

Polymer Principles in Drug Delivery

药物递送正在逐渐成熟为一门工程科学,主要根据药理学的要求,利用材料科学的基本原理来进行递送体系设计和研究。高分子是药用材料的主要类别,本文以药物-高分子固体分散体和高分子药物为例,讨论了高分子科学中的基本原理,尤其是结构与性能关系,是如何在药物递送研究和设计中得以体现的。另一方面,药物递送领域的发展也对高分子科学提出了新的要求,两个学科是互相促进发展的。

Drug delivery has matured and become an engineering science, which utilize basic principles of material science to design the delivery system according to the pharmacology requirements. Since polymer is essential for most of the drug delivery systems, it is important to understand how polymer principles are used to study drug delivery and develop new technologies. Here we used drugpolymer solid dispersion and polymer drugs as two examples to emphasize that the structure-property relationship, the central dogma of polymer science, is also the key for drug delivery.