自发性高血压大鼠脑出血后NF-κBmRNA的变化及安宫牛黄丸的干预作用被引量：3

Effect of Angong Niuhuang Pill on NF-κB mRNA after Acute Intracerebral Hemorrhage in Spontaneously Hypertensive Rats

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摘要目的观察安宫牛黄丸对自发性高血压大鼠脑出血后NF-κBmRNA表达及血压变化的影响。方法以自体血制作大鼠脑出血模型,将成功模型随机分为模型组、西药治疗组、中药治疗组、中西药治疗组,使用尾袖法监测大鼠血压变化,RT-PCR测定NF-κBmRNA的表达。结果与模型组相比,各治疗组NF-κBmRNA表达明显增加(P<0.05),各治疗组间差异无统计学意义(P>0.05),造模后1d、2d、3d自发性高中药治疗组血压较模型组降低(P<0.05),造模后2d、3d西药治疗组血压较中药治疗组低(P<0.05),中西药治疗组血压则处于最低水平(P<0.05)。结论安宫牛黄丸能够防止SHR大鼠脑出血后血压继发性升高,提高NF-κBmRNA的表达,对脑出血的治疗具有一定的意义。 Objective To study the effect of Angong Niuhuang pill on blood pressure and expression of nuclear factor-kappa B（NF-κB） mRNA after intracerebral hemorrhage（ICH） in spontaneously hypertensive rats（SHR）.Methods Models with experimental ICH of rats were established by autologous blood.Rat models were randomly divided into 4 groups： Model group（group A）,western medicine treatment group（group B）,Chinese medicine treatment group（group C）,integrated Chinese medicine and western medicine treatment group（group D）.The expression of NF-κB mRNA in brain tissue was measured by RT-PCR.Results Compared with model group,the expression of NF-κB mRNA in all treatment groups was significantly increased（P0.05）.There was no differences among all treatment groups（P0.05）.The blood pressure in group C was lower than that in model group at first,second and third day（P0.05）.The blood pressure in group B was lower than that in group C at second day and third day（P0.05）.The blood pressure in group D was lower than that in group B and group C at second day and third day（P0.05）.Conclusion Angong Niuhuang pill could prevent blood pressure of SHR rats to increase after ICH,and increase the expression of NF-κB mRNA in SHR.

作者刘远新杨晓燕刘佳张云桥刘婷李卉姜涛

机构地区新疆医科大学附属中医医院

出处《中西医结合心脑血管病杂志》 2011年第1期66-68,共3页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基金国家自然科学基金项目(No.30760315)

关键词安宫牛黄丸核转录因子ΚB 脑出血自发性高血压大鼠 Angong Niuhuang pill nuclear factor-kappa B intracerebral hemorrhage spontaneously hypertensive rats

分类号 R285.5 [医药卫生—中药学]

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