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妊娠期糖尿病患者磷脂酰肌醇-3激酶与胰岛素抵抗的关系 被引量：3

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摘要 妊娠期糖尿病（gestational diabetes mellitus，GDM）发病率近年呈上升趋势，越来越多的研究证明，GDM患者比正常妊娠妇女存在更严重的胰岛素抵抗（insulinresistance，IR）。国内外多数研究认为，胰岛素信号传导减弱或受阻是导致IR的最主要的分子生物学原因。
作者 初永丽 崔青 冯桂姣 王彦 姜学强
机构地区 山东省烟台毓璜顶医院妇产科
出处 《中华围产医学杂志》 CAS 2011年第4期237-239,共3页 Chinese Journal of Perinatal Medicine
基金 基金项目：山东省青年博士基金（2006BS03053）
关键词 妊娠期糖尿病 磷脂酰肌醇-3激酶 胰岛素抵抗 患者 胰岛素信号传导 正常妊娠妇女 分子生物学 发病率
分类号 R714.25 [医药卫生—妇产科学]
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参考文献12

  • 1Goodyear LJ,Giorgino F,Sherman LA,et al.Insulin receptor phosphorylation,insulin receptor substrate-1 phosphorylation,and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.J Clin Invest,1995,95:2195-2204.
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  • 7Buchanan TA,Xiang AH.Gestational diabetes mellitus.J Clin Invest,2005,115:485-491.
  • 8Smirnakis KV,Martinez A,Blatman KH,et al.Early pregnancy insulin resistance and subsequent gestational diabetes mellitus.Diabetes Care,2005,28:1207-1208.
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  • 10赵曼林,冯玉昆,孙跃萍,吕群英,朱高红,李白鸾.妊娠期糖尿病脂联素水平与胰岛素抵抗[J].中华围产医学杂志,2006,9(6):416-417. 被引量：7

二级参考文献18

  • 1Buchanan TA, Xiang AH. Gestational diabetes mellitus. J Clin Invest, 2005,115:485-491.
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  • 7Shepherd PR. Mechanisms regulating phosphoinositide 3-kinase signaling ininsulin-sensitive tissues. Acta Physiol Seand, 2005,183:3-12.
  • 8Bandyopadhyay GK, Yu JG, Ofrecio J, et al. Increased p85/ 55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin resistant human skeletal muscle. Diabetes, 2005,54:2351-2359.
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共引文献6

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二级引证文献11

中华围产医学杂志
2011年 第4期

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