小儿呼气末七氟醚浓度与脑电双频指数的相关性

Correlation between bispectral index and end-tidal sevoflurane concentration in children

目的研究3～12岁患儿呼气末七氟醚浓度（CETSev）和脑电双频指数（BIS）的相关性。方法择期全麻手术患儿30例，按照年龄分为3～6岁组（A组）和7～12岁组（B组）。两组均给予七氟醚诱导，气管插管后调节CETSev分别维持在1．5％、2％、3％、4％、5％至少5min，随后记录B1s、HR、MAP。结果两组患儿BIS在麻醉诱导后均显著降低（P〈0．01）.CETSev在1．5％～3％时，两组患儿BIS均与CETSev呈负相关，A组回归方程为Y（BIS）=94．683～20．656X（CETSev）（r=-0．952，P〈0．01），B组回归方程为Y（BIS）=93．508—19．943X（CETSev）（r=-0．926，P〈0．01）。结论3～12岁小儿应用七氟醚麻醉时，BIS在一定浓度范围内可用于麻醉深度的监测。

Objective To analyse the correlation between BIS and the depth of sevoflurane anaesthesia in younger and older children respectively by observing the bispectral index （BIS） values at the different end-tidal sevoflurane concentration. To evaluate the validation of bispectral index （BIS） monitoring in children anesthetized with sevoflurane. Methods Thirty patients undergoing elective surgery（ASA I or ID were divided into two groups by agewith younger children（3≤age≤6, group A, n= 15） and older children（7≤age≤12, group B, n=15）. All of the patients were induced by sevoflurane 8% combined with rocuronium 0. 6 mg/kg. After intubation, sevoflurane was titrated to generate an end tidal concentration （CETSev）of 1.5%,2%,3%,4%,5%. Each CET Sev was kept for at least 5 min. BIS values and other parameters were recorded before induction and every steady state of end-tidal sevoflurane concentrations. Results The BIS values significantly decreased after induction in both groups （P〈0. 01）. When CETSev was between 1.5%- 3%, the linear regression analysis showed a significant negative correlation between BIS and CETSev. The regression formula is Y（BIS）=94. 683-20. 656X（CETSev） （r=-0. 952, P〈0.01 ） for group A, and Y（BIS） = 93. 508- 19. 943X（CETSev） （r= - 0. 926, P〈0. 01） for group B. ）Conclusion BIS could be used to monitor the depth of anesthesia in children aged 3-12 under sevoflurane anesthesia in a certain CETSev concentration.