天津地区胃癌危险因素病例-对照研究

Risk Factors for Gastric Cancer in Tianjin Area: A Case-control Study

目的从天津地区胃癌发病的危险因素方面探讨胃癌的发病机制,旨在为胃癌的病因学研究和防治工作提供线索和依据。方法对天津地区100例胃镜检查或手术后,经病理检查确诊为胃癌患者为病例组,并以同期胃镜诊断为慢性浅表性胃炎和慢性萎缩性胃炎患者109例作为对照组,均通过统一制表进行相关因素的问卷调查,专人登记。对调查结果进行了Logistic回归分析,以确定饮食、情绪、生活习惯等危险因素与胃癌发生的关系。结果嗜酒和有恶性肿瘤家族史均会很大程度上增加患胃癌的危险性,嗜酒(酒精量>40 g/d)患胃癌的OR值是2.448(95%CI:1.157～5.182),直系亲属患恶性肿瘤发生胃癌的OR值是3.469(95%CI:1.392～8.644)。结论嗜酒和有恶性肿瘤家族史均会很大程度上增加患胃癌的危险程度。

Objective To understand the risk factors for gastric cancer in Tianjin area. Methods 100 patients, all pathologically diagnosed as gastric cancer by way of gastroscopy or surgery, and 109 cases of ehronic superficial gastritis or chronic atrophic gastritis, all gastroscopically diagnosed at the same period, were selected and investigated by questionnaire. The data was analyzed by Logistic regression method. Results The results showed the risk factors for gastric cancer in Tianjin included： alcohol drinking （amount of alcohol 〉40g/day, 0R=2.448, 95%CI： 1.157-5.182） and familiar history of malignant cancer （0R=3.469, 95%CI： 1.392-8.644）. Conclusion Alcohol abuse and family history of malignant tumor may increase the risk of gastric cancer.