坦索罗辛在输尿管下段结石辅助排石的疗效

Efficacy of tamsulosin on assisted expulsion for treating lower ureteral stones

目的评价坦索罗辛在输尿管下段结石辅助排石的疗效。方法 60例输尿管下段结石患者随机分2组,每组30例,结石直径0.4-1.0cm。对照组给予氟罗沙星(0.2g2次/d)及尿石通(4g3次/d)治疗;坦索罗辛组在上述治疗基础上加用坦索罗辛(0.4mg,1次/d)。所有患者观察2周。结果对照组排石率为40%(12/30),坦索罗辛组为排石率83%(25/30),两组比较排石率差异有显著性(P<0.01)。排石时间于对照组、坦索罗辛组分别为10.20±2.13d、5.52±1.87d,两组比较差异有显著性(P<0.05),2周内再次发生肾绞痛而需镇痛治疗者分别为8例(27%)、和2例(7%),组间比较差异有统计学意义(P<0.05)。2组患者在2周内均未出现明显不良反应,无因不能耐受而退出者。结论坦索罗辛在输尿管下段结石辅助排石方面安全性高,并能明显提高排石率。

Objective To evaluate the efficacy of tamsulosin in treatment of distal ureteral calculi.Methods A totalof 60 patients with stones（0.4-1.0 cm in diameter） located in the lower ureter were randomly divided into 2 groups（30 cases in each group）.In the group A（control group）,the patients were treated with fleroxacin（0.2 g 2 bid） and chinese medcine niaoshitong（4 g 3 tid）;In the group B（treatment group）,the patients received the same medicines in group A plus tamsulosin（0.4 g gid）.All patients were followed up for 2 weeks.Results During the observation period,the expulsive calculi rate in control group 40% was significantly（P0.01） lower than that of treatment group 83%.The incidence of renal colic was significantly higher in the control group（27%） than that of the treatment group（7%）.There was statistically significant difference between two groups（P0.05）.Mean expulsive calculi time of the control group and the trentment group were 10.20±2.13day、5.52± 1.87 days respectively.There was statistically significant difference（P0.05）.All the patients could tolerate the expulsive calculi therapy and no obvious side effects were found.Conclusion Tamsulosin in the treatment of lower ureteral stones（0.4-1.0 cm in diameter） is safe and tamsulosin can significantly improve the expulsive calculi rate in the lower ureter.