α-卤代对甲苯磺酰甲基异腈的合成

Synthesis of α-Halogenated p-Toluenesulfonylmethyl Isocyanide

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摘要 TosMIC(对甲苯磺酰甲基异腈)是一种多用途的合成试剂,由于它含有一个异氰基及一个巯基离去集团—Tos,因此在化学合成中有着广泛的应用,受到化学工作者们越来越多的关注。文章以TosMIC为原料,以醋酸铵为催化剂,在室温下分别与N-卤代丁二酰亚胺(NIS,NBS,NCS等)反应,合成了主要产物α-卤代对甲苯磺酰甲基异腈。 TosMIC as an important organic chemical raw materials and intermediates,in many aspects of a wide range was applied.A novel organic compound α-Halogenated p-Toluenesulfonylmethyl isocyanide was synthesized by the reaction of TosMIC with N-halogenated Succinimide,with ammonium acetate as the catalyst.

作者高瑞

机构地区同济大学化学系

出处《广东化工》 CAS 2011年第4期88-88,124,共2页 Guangdong Chemical Industry

关键词 TOSMIC 醋酸铵 α-卤代反应 TosMIC ammonium acetate α-halogenation

分类号 TQ247.52 [化学工程—有机化工]

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广东化工

2011年第4期

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α-卤代对甲苯磺酰甲基异腈的合成

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