有暴力行为的男性青少年神经生化与认知功能

Study of neurochemistry and executive cognitive function in aggression and violence in male delinquents

目的：探索男性不良青少年暴力行为的神经生化、神经内分泌及神经心理学基础。方法：以88例有官方暴力型违法乱纪记录的青少年为研究组,以68例职业高中生为对照组,对两组进行血小板5-HT浓度和血清甲状腺素（T4）、三碘甲状腺原氨酸（T3）、血清促甲状腺素（TSH）、血清睾酮（testos-terone,T）测定,以及威斯康星卡片分类测验（WCST）,并比较两组的异同。结果：与对照组相比,研究组血小板5-HT高、血清T4低、TSH高（P〈0.05~0.01）。WCST击中率（正确反应数/总反应数）低、持续错误数多（P〈0.01）。逐步回归分析显示血小板5-HT含量高、威斯康星卡片测验的总反应数和持续错误数高对青少年攻击行为有显著预测作用（P〈0.05）。结论：有暴力攻击行为的男性不良青少年中枢5-HT功能和额叶执行认知功能降低。

Objective： To investigate serotonergic,thyroid,testosterone and executive cognitive function the aggression and violence in male delinquents. Method：Eighty-eight male delinquents with official records of violent violation as a study group and 68 normal controls were determined by platelet serotonin content,serum thyroxine（T4）,triiodothyronine（T3）,thyrotropin（TSH）,testosterone（T） level,and Wisconsin card sorting test（WCST）. Results：ompared with the control group,the male delinquents with aggressive and violent behavior had higher platelet concentration,higher serum TSH and lower T4（P0.05 or P0.01）.The study group also was characterized by decreased hit rates and higher persistent errors of WCST（P0.05）.Stepwise regression analysis showed that increased platelet serotonin content,higher total reactions and higher persistent errors of WCST contributed significantly to aggression and violence in male delinquents（P0.01）. Conclusion：Decreased serotonergic function,impaired frontal executive cognitive function may partly underlie the neurobiological genesis of aggressive and violent behavior among male delinquents.