22例儿童甲状腺癌临床病理分析

Analysis of Clinic Pathology Features of Thyroid Carcinoma in Children

为探讨儿童甲状腺癌的临床病理特点、预后相关因素,回顾性总结了22例儿童甲腺状癌患者的临床病理特征及预后。结果显示,22例经病理组织学检查证实为儿童甲状腺癌的患者中,有4例为术前穿刺标本病理诊断为甲状腺癌,18例为术中病理冰冻切片诊断为甲状腺癌。22例均行手术切除治疗,其中19例为乳头状癌,2例为滤泡癌,1例髓样癌,淋巴结转移者6例,被膜有浸润者3例。术后平均随访38.1±4.5月,有5例复发,未有死亡病例。结论:儿童甲状腺癌经手术治疗预后较好,分化程度、区域淋巴结转移情况与预后密切相关;术中病理冰冻切片诊断是确诊甲状腺癌的最佳方法。

To investigate the clinic pathologic features and the prognosis of thyroid carcinoma in children,the clinic pathologic characteristics in 22 cases of thyroid carcinoma in children were analyzed.The results showed that 22 patients were confirmed as thyroid carcinoma by pathological examination.Four cases were confirmed by core needle biopsy before operation and 18 cases were confirmed by frozen section during operation.All patients underwent surgical treatment.19 cases were papillary thyroid carcinoma（PTC）,two cases were follicular thyroid carcinoma（FTC）,and one case was medullary thyroid carcinoma（MTC）.6 cases patients were with lymph node metastasis and 3 cases with capsule invasion.The mean postoperative follow-up was about 38.1 months.All patients survived,and 5 cases had local recurrence after surgery.Thyroid carcinoma in children can be cured through curative resection,and the degree of differentiated and node metastasis play key roles in prediction of prognosis.The confirmation of thyroid carcinoma by frozen section during operation is the best way in diagnosis of thyroid carcinoma.