一氧化氮合酶与脓毒症的研究进展

The research progress of NOS and Sepsis

脓毒症在外科临床工作中较常见,治疗相当困难;本文主要概述了一氧化氮合酶的基因定位、结构特点以及一氧化氮合酶与脓毒症的关系,进一步说明由一氧化氮合酶介导的一氧化氮生成与脓毒症关系密切,而选择性一氧化氮合酶抑制剂在脓毒症各阶段恰当的应用可能是有效治疗脓毒症、降低病死率的一个重要途径,也将成为今后研究的热点。

Sepsis is commonly seen in clinical surgery,it is very difficult to be cured.The genic location and the structure features of NOS（nitric oxide synthase） and the relationship between NOS and sepsis were reviewed in this article,we found that sepsis was related closely with the producing of nitric oxide induced by selective nitric oxide synthase inhibitors,and appropriate using of selective nitric oxide synthase inhibitors in each phase of sepsis might be an important way to cure sepsis and cut down its mortality,which could be a focus in future study.