每日短信提醒服药对精神分裂症患者复发的预防效果

Effects of Daily Short Message Reminder for Preventing Schizophrenia Recrudescence

目的探讨每日短信提醒服药对出院后精神分裂症患者复发的预防作用。方法将91例临床痊愈的精神分裂症患者随机分为干预组（43例）和对照组（48例）,两组患者均接受抗精神病药物维持治疗并电话和门诊随访2年,干预组给予每日短信提醒督促服药干预。采用生存分析法比较两组患者的无复发生存时间,用Log-Rank检验比较两组患者的复发率。结果干预组和对照组的2年复发率分别为35.8%（95%可信区间为20.1%~51.5%）和61.2%（95%可信区间为46.9%~75.5%）,Log-Rank检验显示两组复发率差异具有统计学意义（χ2=4.30,P=0.039）。结论每日短信提醒服药能有效预防精神分裂症患者的复发。

Objective To explore the prophylactic effect of daily short message（DSM） reminder for schizophrenia recrudescence.Methods Ninety-one discharged patients with clinically cured schizophrenia were randomly assigned to intervention group（n=43） and control group（n=48）.Both groups were given antipsychotic treatment and followed up by telephone and outpatient service.The intervention group was given DSM reminder for surpervising drug taking additionaly.Survival analysis and Log-Rank test were used to compare the relapse-free survival time and the recrudescence rate of the two groups respectively.Results The two year recrudescence rates（95% confidence interval） for the intervention and the control group were 35.8%（20.1%-51.5%） and 61.2%（46.9%-75.5%）,respectively.Log-Rank test showed their difference had statistical significance（χ2=4.30,P=0.039）.Conclusion DSM reminder can prevent schizophrenia recrudescence effectively.