胃康宁颗粒抗实验性胃溃疡作用研究

An experimental Study on the Effect of Weikangning Granules on Gastric Ulcer

目的:研究胃康宁颗粒抗实验性溃疡的作用。方法:采用小鼠水浸应激法、大鼠幽门结扎法、醋酸致大鼠胃溃疡法建立动物胃溃疡模型,观察胃康宁颗粒对胃溃疡的保护作用;小鼠扭体法观察胃康宁颗粒的镇痛作用。以豚鼠肠道活动力为指标,观察胃康宁颗粒对回肠平滑肌收缩的影响;结扎幽门,观察胃康宁颗粒对大鼠胃液分泌的影响。结果:胃康宁颗粒对小鼠水浸应激性溃疡、结扎大鼠幽门引起的溃疡和醋酸致大鼠胃溃疡均有明显的保护作用,能降低大鼠胃溃疡指数,减少溃疡面积;可降低醋酸致小鼠扭体反应的次数;能兴奋豚鼠回肠平滑肌;显著减少总胃酸度和胃蛋白酶活性。结论:胃康宁颗粒具有抗实验性胃溃疡的作用。该作用可能与其减少总胃酸度和胃蛋白酶活性、解痉作用和镇痛作用有关。

Objective:To study the effect of Weikangning Granules on Gastric Ulcer.Methods: The animal gastric ulcer models were established by mice water immersion,rat pylorus ligation and gastric ulcer rats induced by acetic acid to observe the protective effect of the granules on gastric ulcer and a mice writhing method to observe the analgesic effect of the granules.Guinea pigs methods were used as an indicator of intestinal motility to observe the effect of ileum smooth muscle contraction.A pyloric ligation was used to observe the effect on the secretion of gastric juice.Results: Weikangning had an obvious protection for the stomach ulcer induced by mice flooding stress ulcer,pyloric ligation and gastric ulcer induced by acetic acid,and could reduce the gastric ulcer index and decrease the ulcer area,and also reduce the number of the rat writhing,excite the ileum smooth muscle of the guinea pig,significantly reduce the total acidity and pepsin activity.Conclusions: Weikangning Granules have an anti-gastric ulcer effect,which may be related to the reduction of the total acidity and pepsin activity as well as antispasmodic and analgesic effects.