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AZF基因与男性不育的研究进展 被引量:1

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摘要 Y染色体是男性特有的染色体,其上含有与精子发生相关的基因.越来越多研究证实AZF区基因微缺失与男性不育密切相关。目前明确的微缺失包括AZFa、AZFb、AZFc和AZFd这4个区域及其候选基因。本文综述了Y染色体AZF基因微缺失与男性不育的研究进展,为临床诊断、治疗男性不育症提供理论依据。
机构地区 解放军第
出处 《中国优生与遗传杂志》 2011年第4期4-5,共2页 Chinese Journal of Birth Health & Heredity
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参考文献15

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二级参考文献16

  • 1Tiepolo L, Zuffardi O. Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm[J]. Hum Genet, 1976,34(2): 119-124
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  • 9Ferlin A, Movo E, Rossi A, et al. The humarl Y chromoosome' s azoospermia factor b(AZFb)region: sequence, structure, and deletion analysis in infertile men. J Med Genet,2003,40:18-24.
  • 10Tiepolo L, Zuffardi O. Localization of factors controlling spennatogenesis in the nonfluorescent portion of the human Y chromosome long ann. Hum Genet, 1976, 34:119-124.

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