sICAM-1、U-ALB在妊娠期高血压疾病早期肾损伤中的变化及相关性研究

The study of changes and correlation betwee sICAM-1,U-ALB in pregnancy induced hypertension with early renal injury

目的探讨妊娠期高血压疾病早期肾损伤中尿微量白蛋白(U-ALB)与可溶性细胞间粘附因子-1水平变化及相关性分析。方法测定正常妊娠组、妊娠期高血压组U-ALB含量;测定正常未孕组、正常妊娠组、妊娠期高血压组、子痫前期组4组(孕32-35周)sIACM-1值;所测值进行组间比较并对sIACM-1、U-ALB进行相关性分析。结果妊娠期高血压患者U-ALB阳性率(60.00%)明显高于正常妊娠组(10.00%),P<0.01;sIACM-1正常妊娠组高于未孕组,P<0.05;与正常妊娠组比较,妊娠期高血压组高于正常妊娠组,P<0.05;子痫前期组明显高于正常妊娠组,P<0.01;与妊娠高血压组比较P<0.05。妊娠期高血压组sIACM-1与U-ALB相关性分析,相关系数(r)为0.723;P值<0.01。结论 U-ALB、sIACM-1在妊娠期高血压疾病早期肾损伤中含量明显增高,两者之间呈正相关。

Objective： To investigate the early renal injury in hypertensive disorders in pregnancy in the urine albumin（U-ALB） and soluble intercellular adhesion molecule-1 levels and correlation analysis.Methods： Determined the normal pregnancy group,gestational hypertension group U-ALB levels;determination of the normal nonpregnant group,normal pregnancy,gestational hypertension,preeclampsia group 4（32-35 weeks gestation） sIACM-1 value;The measured value of the comparison between groups and sIACM-1,U-ALB correlation analysis.Results：Gestational hypertension U-ALB-positive rate（60.00%） was significantly higher than the normal pregnancy group（10.00%）,P〈0.01;sIACM-1 higher than those of normal pregnancy and pregnancy group,P〈0.05;with normal pregnancy compared with gestational hypertension group was higher than the normal pregnancy group,P〈0.05;preeclampsia group were significantly higher than the normal pregnancy group,P〈0.01;and pregnancy induced hypertension group P〈0.05.Gestational hypertension group sIACM-1 and U-ALB correlation analysis,correlation coefficient（r） was 0.723;P value 0.01.Conclusion： U-ALB,sIACM-1 early in pregnancy induced hypertension were significantly higher in the renal injury,a positive correlation between the two.