泉州地区9338例孕中期产前筛查回顾性分析

Retrospective analysis of prenatal screening on 9338 cases in the city of Quanzhou

目的评价妊娠中期孕妇血清(AFP/Free-β-hCG)二联法筛查在唐氏综合征、18-三体综合征和神经管缺陷的临床应用价值。方法采用双标记时间分辨荧光法对9338例孕周15～20+6周的孕妇进行血清AFP和Free-β-hCG浓度的检测,并结合孕周、体重、年龄等因素,通过风险评估软件进行风险评估。结果 9338例孕中期孕妇中,阳性率为4.7%(437/9338)。筛查出唐氏综合征高风险262例,阳性率2.8%,神经管缺陷高风险119例,阳性率1.3%,18-三体高风险56例,阳性率0.6%。结论利用孕妇孕中期两种血清标志物的检测对孕妇进行产前筛查可以有效地降低缺陷儿的出生率。

Objective： To evaluate the clinic value of the double marker prenatal screening system for Down′s syndrome（DS）,trisomy 18 and neural tube defects（NTD）.Methods： Double label time-resolved fluorescence method was used to test the concentrations of AFP and Free-β-hCG in the serum of 9338 middle period pregnant women who were pregnant for 15-20＋6 weeks.combined with gestational age,weight,age and other factors,we evaluated the risk assessment with assessment software.Results： In 9338 cases,the positive rate 4.7%（437/9338）,with 2.8%（262 cases）of Downs syndrome and 1.3%（119 cases） of NTD and 0.6%（56 cases） of 18-trisome syndrome.Conclusion： The combination of the serum biochemistry results of AFP and Free-β-hCG can effectively reduce congenital fetal malformtion.